| 產(chǎn)品編號 | bs-1693R-AP |
| 英文名稱 | Rabbit Anti-CANX/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的鈣連蛋白抗體 |
| 別 名 | Calnexin-ER membrane marker; CALNEXIN; CANX; Cell adhesion molecule with homology to l1cam precursor; CNX; D11Ertd153e; 1110069N15Rik; AI988026; FLJ26570; IP90; P90; Similar to calnexin; Major histocompatibility complex class I antigen-binding protein p88; CALX_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 染色質(zhì)和核信號 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CANX |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq] Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Subunit: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. Subcellular Location: Endoplasmic reticulum membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Post-translational modifications: Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). br>Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. Similarity: Belongs to the calreticulin family. Database links: Entrez Gene: 821 Human Entrez Gene: 12330 Mouse Omim: 114217 Human SwissProt: P27824 Human SwissProt: P35564 Mouse Unigene: 567968 Human Unigene: 248827 Mouse Unigene: 1762 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 內(nèi)質(zhì)網(wǎng)膜蛋白標(biāo)志物（ER membrane marker） 鈣連蛋白 calnexin 存在于內(nèi)質(zhì)網(wǎng)中，是內(nèi)質(zhì)網(wǎng)膜標(biāo)志物，屬于Ca2+的凝集素樣分子伴侶蛋白，可結(jié)合蛋白質(zhì)的寡糖鏈 ，防止蛋白質(zhì)彼此聚集和泛素化，避免折疊不完全的蛋白質(zhì)離開內(nèi)質(zhì)網(wǎng)。 |
