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Rabbit Anti-NCX1/BF594 Conjugated antibody (bs-1550R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1550R-BF594
英文名稱1 Rabbit Anti-NCX1/BF594 Conjugated antibody
中文名稱 BF594標記的鈉鈣交換蛋白1抗體
別    名 Na+/Ca2+exchanger 1; CNC; DKFZp779F0871; MGC119581; FLJ37694; FLJ43417; Na+/Ca2+ exchange protein 1; Na+/Ca2+ exchanger; NCX 1; NCX; SLC8A1; SLC8A1 protein; Sodium Calcium Exchanger; Sodium/calcium exchanger 1; Solute carrier family 8 member 1; NAC1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學  轉(zhuǎn)運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, G)
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 106kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NCX1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma(plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM].

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung.

Similarity:
Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. Contains 2 Calx-beta domains.

Database links:

Entrez Gene: 6546 Human

Entrez Gene: 20541 Mouse

Entrez Gene: 100328570 Rabbit

Entrez Gene: 29715 Rat

Omim: 182305 Human

SwissProt: P23685 Dog

SwissProt: P48766 Guinea pig

SwissProt: P32418 Human

SwissProt: P70414 Mouse

SwissProt: Q01728 Rat

Unigene: 31961 Human

Unigene: 468274 Human

Unigene: 728911 Human

Unigene: 265834 Mouse

Unigene: 118972 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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