| 產(chǎn)品編號(hào) | bs-1500R-BF350 |
| 英文名稱 | Rabbit Anti-Cathepsin B/BF350 Conjugated antibody |
| 中文名稱 | BF350標(biāo)記的組織蛋白酶B抗體 |
| 別 名 | Amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; CB; Cathepsin B1; CathepsinB; CPSB; CTSB; Cysteine protease; Preprocathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; CATB_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 合成與降解 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23/28/37kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cathepsin B heavy chain |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Subcellular Location: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the peptidase C1 family. Database links: Entrez Gene: 1508 Human Entrez Gene: 13030 Mouse Omim: 116810 Human SwissProt: P07858 Human SwissProt: P10605 Mouse Unigene: 520898 Human Unigene: 236553 Mouse Unigene: 472420 Mouse Unigene: 100909 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） 組織蛋白酶B(CB) 參與腫瘤的侵襲轉(zhuǎn)移過(guò)程。可促進(jìn)腫瘤血管的增生，增強(qiáng)腫瘤細(xì)胞的運(yùn)動(dòng)能力.組織蛋白酶B轉(zhuǎn)錄以及表達(dá)水平的高低與腫瘤預(yù)后呈正相關(guān)。 cathepsin B屬于半胱氨酸蛋白酶,與人體的多種生理、病理過(guò)程密切相關(guān).組織蛋白酶B (cathepsin B,CB)主要存在于溶酶體中, 發(fā)揮其生理狀態(tài)下的蛋白水解作用.但在某些特定條件下, CB在胞外間質(zhì)中有時(shí)也可以檢測(cè)到. 目前，有學(xué)者將CB用于阿爾茨海默病（AD）方面的研究。 |
