| 產(chǎn)品編號 | bs-1303R-AP |
| 英文名稱 | Rabbit Anti-SFRP1/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的分泌型卷曲相關(guān)蛋白1抗體 |
| 別 名 | Secreted frizzled related protein 1; Frizzled related protein 1; FRP 1; SARP 2; SARP-2; Secreted apoptosis related protein 2; Secreted Apoptosis-related Protein 2; Secreted frizzled related protein; Secreted Frizzled-related Protein 1; Secreted frizzled-related protein; SFRP 1; sFRP-1; SFRP1; SFRP1_HUMAN; SFRP1; FRP; FRP-1; FRP1; FrzA; SARP2. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SFRP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Subunit: Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Subcellular Location: Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding. Tissue Specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Similarity: Belongs to the secreted frizzled-related protein (sFRP) family. Contains 1 FZ (frizzled) domain. Contains 1 NTR domain. Database links: Entrez Gene: 6422 Human Entrez Gene: 20377 Mouse Omim: 604156 Human SwissProt: Q8N474 Human SwissProt: Q8C4U3 Mouse Unigene: 213424 Human Unigene: 281691 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 分泌型卷曲相關(guān)蛋白1是近來發(fā)現(xiàn)的新的抑癌基因, 是Wnt信號通道的拮抗通路蛋白,SFRP1能夠阻斷某些發(fā)生在癌癥初期與之相關(guān)的細(xì)胞生長基因的信號通路。 有學(xué)者認(rèn)為：該基因有去甲基化酶的作用，可以阻斷與甲基化進(jìn)程相關(guān)酶的活性，進(jìn)而抑制腫瘤基因的改變，SFRP1的作用還有待于更進(jìn)一步的研究。 |
