| 產(chǎn)品編號(hào) | V5515 |
| 英文名稱(chēng) | NF-L Rabbit mAb |
| 中文名稱(chēng) | 低分子量神經(jīng)絲蛋白單克隆抗體 |
| 別 名 | Neurofilament L; Neurofilament 68; Neurofilament triplet L; 70 kD Neurofilament Light; 68kDa neurofilament protein; CMT 1F; CMT 2E; CMT1F; CMT2E; FLJ53642; Light molecular weight neurofilament protein; NEFL; Neurofilament light; Neurofilament light polype |
| 克 隆 號(hào) | 8A4 |
| 理論分子量 | 68kDa |
| 性 狀 | Liquid |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 0.01M PBS(pH7.4) |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Neurofilament light polypeptide also called NF-L; Neurofilament triplet L protein; 68 kDa neurofilament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions. NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. Belongs to the intermediate filament family. SWISS: P07196 Gene ID: 4747 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） 低分子量神經(jīng)絲蛋白,簡(jiǎn)稱(chēng)NF-L,分子量為68kDa，NF-L的聚集與神經(jīng)退行性疾病的發(fā)病機(jī)理相關(guān)，如運(yùn)動(dòng)神經(jīng)元的降解等。 神經(jīng)纖絲蛋白的功能是提供彈性使神經(jīng)纖維易于伸展和防止斷裂。 神經(jīng)絲是中間纖維的一種重要類(lèi)型又稱(chēng)神經(jīng)微絲蛋白，特異地在神經(jīng)細(xì)胞內(nèi)表達(dá)，并在軸突內(nèi)相互平行排列成束. 哺乳動(dòng)物的神經(jīng)絲由3種蛋白組成： 低分子量神經(jīng)絲蛋白，簡(jiǎn)稱(chēng)NF-L；分子量為68kDa； 中分子量神經(jīng)絲蛋白，簡(jiǎn)稱(chēng)NF-M；分子量為160kDa； 高分子量神經(jīng)絲蛋 |
