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Mouse Anti-TLE1  antibody (bsm-51112M)  
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說明書: 50ul  100ul  
50ul/1180.00元
100ul/1980.00元
大包裝/詢價
產(chǎn)品編號 bsm-51112M
英文名稱 Mouse Anti-TLE1  antibody
中文名稱 轉(zhuǎn)導(dǎo)樣增強(qiáng)蛋白1小鼠單克隆抗體
別    名 TLE 1; E(Sp1) homolog; Enhancer of split groucho 1; Enhancer of split groucho like protein 1; Enhancer of split groucho-like protein 1; ESG; ESG1; GRG1; TLE1; TLE1_HUMAN; Transducin like enhancer of split 1(E(sp1) homolog Drosophila); Transducin like enhancer of split 1; Transducin like enhancer of split 1 homolog of Drosophila E(sp1); Transducin like enhancer protein 1; Transducin-like enhancer protein 1.  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 1C1
交叉反應(yīng) (predicted: Human)
產(chǎn)品應(yīng)用 WB=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 83 kDa
檢測分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLE1 
亞    型 IgG1
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antib
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Spindle Cell Liposarcoma. Among its related pathways are Signaling by Wnt and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.

Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Subunit:
Homooligomer and heterooligomer with other family members.

Subcellular Location:
Nucleus. Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Tissue Specificity:
In all tissues examined, mostly in brain, liver and muscle.

Post-translational modifications:
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Ubiquitinated by XIAP/BIRC4.

Similarity:
Belongs to the WD repeat Groucho/TLE family.
Contains 6 WD repeats.

SWISS:
Q04724

Gene ID:
7088

Database links:

Entrez Gene: 7088 Human

Entrez Gene: 21885 Mouse

Entrez Gene: 362533 Rat

Omim: 600189 Human

SwissProt: Q04724 Human

SwissProt: Q62440 Mouse

Unigene: 197320 Human

Unigene: 689805 Human

Unigene: 278444 Mouse

Unigene: 388819 Mouse

Unigene: 399716 Mouse

Unigene: 6875 Rat



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