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Alpha 1 microglobulin (W6101)  
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產(chǎn)品編號 W6101
英文名稱 Alpha 1 microglobulin
中文名稱 α1微球蛋白抗體
別    名 alpha 1 Microglobulin; Alpha 1 microglobulin/bikunin precursor; Alpha-1 microglycoprotein; AMBP; AMBP_HUMAN; Bikunin; Complex-forming glycoprotein heterogeneous in charge; EDC1; Growth inhibiting protein 19; HCP; HI 30; HI-30; HI30; IATIL; Inter alpha try  
理論分子量 37 kDa
檢測分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
緩 沖 液 0.01M PBS (pH7.4) with 0.02% Proclin300.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 This gene encodes a complex glycoprotein secreted inplasma. The precursor is proteolytically processed into distinctfunctioning proteins: alpha-1-microglobulin, which belongs to thesuperfamily of lipocalin transport proteins and may play a role inthe regulation of inflammatory processes, and bikunin, which is aurinary trypsin inhibitor belonging to the superfamily ofKunitz-type protease inhibitors and plays an important role in manyphysiological and pathological processes. This gene is located onchromosome 9 in a cluster of lipocalin genes.

Function:
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin,and lysosomal granulocytic elastase. Inhibits calcium oxalatecrystallization. Trypstatin is a trypsin inhibitor

Subunit:
I-alpha-I plasma protease inhibitors are assembled fromone or two heavy chains (H1, H2 or H3) and one light chain,bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 andbikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.Alpha-1-microglobulin occurs as a monomer and also in complexeswith IgA and albumin. Alpha-1-microglobulin interacts with FN1.Trypstatin is a monomer and also occurs as a complex with tryptasein mast cells (By similarity). Alpha-1-microglobulin and bikunininteract (via SH3 domain) with HEV ORF3 protein.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the liver and secreted in plasma.Alpha-1-microglobulin occurs in many physiological fluids includingplasma, urine, and cerebrospinal fluid. Inter-alpha-trypsininhibitor is present in plasma and urine.

Post-translational modifications:
The precursor is proteolytically processed into separatelyfunctioning proteins. 3-hydroxykynurenine, an oxidized tryptophan metabolite thatis common in biological fluids, reacts with Cys-53, Lys-111,Lys-137, and Lys-149 to form heterogeneous polycyclic chromophoresincluding hydroxanthommatin. The reaction by alpha-1-microglobulinis autocatalytic; the human protein forms chromophore even whenexpressed in insect and bacterial cells. The chromophore can reactwith accessible cysteines forming non-reducible thioethercross-links with other molecules of alpha-1-microglobulin or withother proteins such as Ig alpha-1 chain C region 'Cys-352'. Heavy chains are interlinked with bikunin via a chondroitin4-sulfate bridge to the their C-terminal aspartate (By similarity). N- and O-glycosylated. N-glycan heterogeneity at Asn-115:Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5(minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of theglycosaminoglycan, chondroitin sulfate, at Ser-215 allowscross-linking between the three polypeptide chains.

Similarity:
In the N-terminal section; belongs to the calycinsuperfamily. Lipocalin family. Contains 2 BPTI/Kunitz inhibitor domains.

SWISS:
P02760

Gene ID:
259

Database links:

Entrez Gene: 259 Human

Entrez Gene: 25377 Rat

Omim: 176870 Human

SwissProt: P02760 Human

SwissProt: Q64240 Rat

Unigene: 436911 Human

Unigene: 18721 Rat



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