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OCT2 Mouse mAb (bsm-34142M)  
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50ul/1180.00元
100ul/1980.00元
大包裝/詢價

產(chǎn)品編號 bsm-34142M
英文名稱 OCT2 Mouse mAb
中文名稱 陽離子轉運蛋白2單克隆抗體
別    名 organic cation transporter OCT2; POU domain, class 2, transcription factor 2; Octamer-binding transcription factor 2; Oct-2; OTF-2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; POU2F2; NF A2; Oct 2; PO2F2_MOUSE; PO2F2_HUMAN.  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 13C4
交叉反應 Human,Mouse
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 51 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OCT2 
亞    型 IgG2b, Kappa
純化方法 affinity purified by Protein A
緩 沖 液 Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Proclin300.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Oct2 is a transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Oct2 regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. It also modulates transcription transactivation by NR3C1, AR and PGR. Oct2 is B cell specific, belongs to the POU transcription factor family class 2 subfamily and contains 1 homeobox domain.

Function:
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.

Subunit:
Interacts with NR3C1, AR and PGR.

Subcellular Location:
Cytoplasm. Nuclear

Tissue Specificity:
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147.

Similarity:
Belongs to the POU transcription factor family. Class-2 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

SWISS:
P09086

Gene ID:
5452

Database links:

Entrez Gene: 5452 Human

Entrez Gene: 18987 Mouse

Entrez Gene: 117058 Rat

Omim: 164176 Human

SwissProt: P09086 Human

SwissProt: Q00196 Mouse

Unigene: 147381 Human

Unigene: 76683 Mouse

Unigene: 155998 Rat



同源結構域蛋白(Homeodomain Proteins)
OCT-2是B淋巴細胞轉錄因子,以免疫球蛋白啟動子為目標,于生發(fā)中心形成和B細胞分化成漿細胞中起作用。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (2-Oct) Monoclonal Antibody, Unconjugated (bsm-34142M) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (2-Oct) Monoclonal Antibody, Unconjugated (bsm-34142M) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse lymphoid); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (2-Oct) Monoclonal Antibody, Unconjugated (bsm-34142M) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
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