| 產(chǎn)品編號 | V6405 |
| 英文名稱 | Human LH Mouse mAb |
| 中文名稱 | 人促黃體生成素β亞基單克隆抗體 |
| 克 隆 號 | 6H1 |
| 理論分子量 | 16 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Lyophilized or Liquid |
| 緩 沖 液 | 0.01M PBS (pH7.4). |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Luteinizing Hormone is a member of the glycoprotein hormone family. Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Mutations in the Luteinizing Hormone (LHB) gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. Subcellular Location: Secreted. Tissue Specificity: Pituitary gland. DISEASE: Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the glycoprotein hormones subunit beta family. SWISS: P01229 Gene ID: 3972 Database links: Entrez Gene: 3972 Human Entrez Gene: 16866 Mouse SwissProt: P01229 Human SwissProt: O09108 Mouse LH和FSH都是垂體前葉產(chǎn)生的，由兩條多肽鏈(即а和β亞單位)經(jīng)非共價鍵結(jié)合的糖蛋白。LH和FSH都是呈脈沖式分泌，故有較明顯的日內(nèi)和日間變異。 女性月經(jīng)中期的LH高峰促成排卵，男性LH主要刺激Legdig細(xì)胞產(chǎn)生睪丸酮，又協(xié)同F(xiàn)SH促進(jìn)精子成熟。與FSH同時測定，是研究和判斷下丘腦 — 垂體 — 性腺軸功能的常規(guī)檢查方法。LH的測定在預(yù)測排卵時間上具有特殊重要意義，它還可用于絕經(jīng)期檢查，不孕癥診斷和內(nèi)分泌治療的監(jiān)測等。 |
