mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
高坂保奈美成熟中文字幕,亚洲日产av中文字幕一区
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-NMDAR1  antibody (bsm-52950R)  
~~~促銷(xiāo)代碼KT202411~~~
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@m.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說(shuō)明書(shū): 25ul  50ul  100ul
25ul/980.00元
50ul/1580.00元
100ul/2500.00元
大包裝/詢(xún)價(jià)

產(chǎn)品編號(hào) bsm-52950R
英文名稱(chēng) Rabbit Anti-NMDAR1  antibody
中文名稱(chēng) 離子型谷氨酸受體1重組兔單抗
別    名 NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Recombinant
克 隆 號(hào) 13C4
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 103kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human NMDAR1 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with MYZAP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in post-synaptic plasma membrane and post-synaptic densities.

Post-translational modifications:
NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

DISEASE:
Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

SWISS:
Q05586

Gene ID:
2902

Database links:

Entrez Gene: 2902 Human

Entrez Gene: 14810 Mouse

Entrez Gene: 24408 Rat

Omim: 138249 Human

SwissProt: Q05586 Human

SwissProt: P35438 Mouse

SwissProt: P35439 Rat

Unigene: 558334 Human

Unigene: 278672 Mouse

Unigene: 9840 Rat



產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with NMDAR1 monoclonal antibody, unconjugated (bsm-52950R) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
Paraformaldehyde-fixed, paraffin embedded Human Left Parietal Lobe; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with NMDAR1?? Monoclonal Antibody, Unconjugated(bsm-52950R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023)and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with NMDAR1?? Monoclonal Antibody, Unconjugated(bsm-52950R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023)and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with NMDAR1?? Monoclonal Antibody, Unconjugated(bsm-52950R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023)and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with NMDAR1?? Monoclonal Antibody, Unconjugated(bsm-52950R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023)and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with NMDAR1?? Monoclonal Antibody, Unconjugated(bsm-52950R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023)and DAB (C-0010) staining.
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲国产精品一区二区三区久久| 午夜在线观看视频在线观看| 久久久久久久性生活| 亚洲AV综合色一区二区三区| 亚洲国产成人久久精品不卡| 精品视频亚洲一区二区三区| 欧美日韩一级裸体黄色视| 日韩一区二区三区久久久| 色欲香天天综合免费区一区二| 99久久国产亚洲精品美女| 久久久久久999一区二区三区| 欧美精品在欧美一区二区三区| 亚洲精品电影一区二区三区| 日本精品一线在线观看| 亚洲精品欧美日韩专区| 国产av一区二区三区久久久久| 精品国产品国语在线不卡| 亚洲影视一区二区三区| 欧美一级黄片在线播放| 亚洲日韩欧美制服第一页| 精品人妻一区二区三区20| 国产av剧情亚洲精品| 日本免码va在线看免费| 国产线精品视频在线观看| 婷婷色婷婷开心五月四房播播| 日韩一二三区中文字幕在线视频精品| 97国产精品国偷自产在线| 久久蜜臀亚洲一区二区| 精品日韩欧美一区在线播放| 88国产精品视频一区二区三区| 久久久久久久性生活| 日韩一区二区三区视频| 超碰人人在线免费观看| 精品国产99高清一区二区三区| 99久久精品视香蕉蕉| 欧美精品专区一区二区| 亚洲精品在线观看日本国产| 国产精品青青青高清在线观看| 在线国产精品一区二区三区| 午夜精品久久久久久久久久久| 久久久成人国产精品麻豆|