| 產(chǎn)品編號(hào) | bsk11022 |
| 英文名稱 | Human IL-1 R4/ST2 ELISA Kit |
| 中文名稱 | 白細(xì)胞介素1受體4酶聯(lián)免疫試劑盒 |
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Specific References (1) | bsk11022 has been referenced in 1 publications.
[IF=1.918] Zefeng Wang. et al. Serum-Soluble ST2 Is a Novel Biomarker for Evaluating Left Atrial Low-Voltage Zone in Paroxysmal Atrial Fibrillation. Med Sci Monitor. 2020; 26: e926221-1–e926221-9 ELISA ; Human.
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| 種 屬 | Human |
| 線性范圍 | 31.20 - 2,000 pg/mL |
| 應(yīng)用范圍 | S/P/CC |
| 檢測(cè)限 | 15 pg/mL |
| 適用樣品基質(zhì) | cell culture supernates, serum, and plasma. |
| 保存條件 | Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.). |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories.IL-1RA is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R), the same receptor that binds interleukin 1 (IL-1), preventing IL-1 from sending a signal to that cell.A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.
Mutations in the IL1RN gene results in a rare disease called deficiency of the interleukin-1–receptor antagonist (DIRA).Variants of the IL1RN gene is also associated with risk of schizophrenia.Elevated levels of IL1RN has been found in serum of schizophrenia patients.An interleukin 1 receptor antagonist is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. It is commercially produced as anakinra, which is a human recombinant form of IL-1RA. In terms of protein similarities, IL-1β is more closely related to IL-1RA than it is to IL- 1α. The amino acids that are identical between mature human IL-1α and mature IL-1β is 22% while it is 26% when comparing IL-1β to IL-1RA and only 18% when comparing IL-1α to IL-1RA.
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