mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日韩欧美有码中文字幕,国产一区国产二区在线
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-Notch 2  antibody (bs-21664R)  
訂購熱線:400-901-9800
訂購郵箱:sales@m.p2b3.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-21664R
英文名稱 Rabbit Anti-Notch 2  antibody
中文名稱 跨膜受體蛋白Notch-2抗體
別    名 Neurogenic locus notch homolog protein 2; activated Notch 2; Notch2; hN2; Notch 2 extracellular truncation; Notch 2 intracellular domain; AGS2; hN2; Motch B; N2 antibody neurogenic locus notch homolog protein 2; NOTC2_HUMAN; Notch 2; Notch Drosophila homolog 2; Notch homolog 2; Notch homolog 2 Drosophila.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 262 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Notch 2: 2070-2170/2471 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Subunit:
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity).Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65 (By similarity).

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Notch 2 intracellular domain: Nucleus.

Tissue Specificity:
Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Post-translational modifications:
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).

DISEASE:
Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2) [MIM:610205]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

Similarity:
Belongs to the NOTCH family.
Contains 6 ANK repeats.
Contains 35 EGF-like domains.
Contains 3 LNR (Lin/Notch) repeats.

SWISS:
Q04721

Gene ID:
4853

Database links:

Entrez Gene: 4853 Human

Entrez Gene: 18129 Mouse

Omim: 600275 Human

SwissProt: Q04721 Human

SwissProt: O35516 Mouse

SwissProt: Q9QW30 Rat

Unigene: 487360 Human

Unigene: 485843 Mouse



產(chǎn)品圖片
Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti- Notch 2 (bs-21664R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 262 kD Observed band size: 262 kD
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
色噜噜在线一区二区三区| 日本熟人妻中文字幕在线| A级毛片毛片免费观看久| 大鸡吧视频在线观看| 日韩中文字幕一区二区高清| 免费看澡美女逼视频看看| 免费看澡美女逼视频看看| 把女生操出水的视频| 久久久18禁一区二区网| 裸体午夜一级视频| 精品国产自在现线看| 精品免费久久久久久久久| 国产精品无码av在线一区| 一级美女插逼百度| 几巴怪物操逼视频| 亚洲国产成人久久成人52| 午夜性无码视频在线播放| 骚逼毛茸茸乱伦视频| 最是人间烟火色在线播放| 黄色视频力肏女人| 又爽又粗又大又长的爆草| 大鸡吧小骚逼视频| av中文字幕一区二区精品久久| 欧美精品一区二区三区四区五区| 欧美真人性爱视频| 国产一区二区三区 韩国女主播| 操世界最美丽的逼片| 中文字幕你懂的av一区二区| 校花内射国产麻豆欧美一区| 久久一区二区三区精华液介绍| 操烂嫩逼内射视频| 国产精品操大屁股老淑女| 女人被男人躁爽色欲国产| 欧美国产综合日韩一区二区| 农村胖肥胖女人操逼视频| 黑人猛操日本美女| 白嫩在线亚洲观看| 97人人澡人人爽人人揉| 日韩精品高清在线| 大鸡扒干美女BB直流水| 免费骚逼潮吹av|