| 產(chǎn)品編號 | bsm-30072M-PE |
| 英文名稱 | human CD10/PE |
| 中文名稱 | PE標(biāo)記人CD10單克隆抗體 |
| 別 名 | Atriopeptidase; CALLA; CD 10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; EC 3.4.24.11; Enkephalinase; EPN; gp100; Membrane metallo endopeptidase; Membrane metalloendopeptidase; Membrane metalloendopeptidase neutral endopeptidase enkephalinase; Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10; Membrane metalloendopeptidase variant 1; Membrane metalloendopeptidase variant 2; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase 24.11; Neutral endopeptidase; NEP_HUMAN; Neprilysin; Skin fibroblast elastase; SFE. PE anti-human CD10; |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 干細(xì)胞 細(xì)胞表面分子 細(xì)胞類型標(biāo)志物 淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | HIT10a |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 82kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD10-PE |
| 亞 型 | IgG1 |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017] Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Post-translational modifications: Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. Similarity: Belongs to the peptidase M13 family. SWISS: P08473 Gene ID: 4311 Database links: Entrez Gene: 4311 Human Omim: 120520 Human SwissProt: P08473 Human Unigene: 307734 Human |
| 產(chǎn)品圖片 |
Flow cytometry staining of normal human peripheral blood cells with CD10/PE (bsm-30072M-PE)(Red histogram) or Mouse IgG1 Isotype Control (PE Conjugate)(C03-11002
)(Blue histogram) . Total cells were used for analysis.
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