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    Mouse Anti-CBARA1/MICU1  antibody (bsm-33198M)  
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    產(chǎn)品編號 bsm-33198M
    英文名稱 Mouse Anti-CBARA1/MICU1  antibody
    中文名稱 線粒體鈣吸收蛋白單克隆抗體
    別    名 Mitochondrial Calcium Uptake 1; Calcium-Binding Atopy-Related Autoantigen 1; Atopy-Related Autoantigen CALC; Ara CALC; CBARA1; CALC; Calcium Binding Atopy-Related Autoantigen 1; Calcium Uptake Protein 1, Mitochondrial; Allergen Hom S 4; EFHA3; MPXPS; MICU1_HUMAN;  
    研究領域 細胞生物  信號轉(zhuǎn)導  新陳代謝  線粒體  
    抗體來源 Mouse
    克隆類型 Monoclonal
    克 隆 號 1H8
    交叉反應 Human (predicted: Mouse,Rat)
    產(chǎn)品應用 WB=1:500-1000
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 54 kDa
    檢測分子量
    細胞定位 細胞漿 線粒體
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 Recombinant human CBARA1 Protein (1-250/476) 
    亞    型 IgG
    純化方法 affinity purified by Protein G
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]

    Function:
    Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

    Subunit:
    Homohexamer; in absence of calcium (PubMed:24514027). Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium (PubMed:26489515, PubMed:24514027). Heterodimer; disulfide-linked; heterodimerizes with MICU2 (PubMed:24560927). The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (PubMed:26387864). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed:24231807). Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct (PubMed:27099988). Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2 (PubMed:21685886, PubMed:23101630, PubMed:23178883, PubMed:24332854, PubMed:26387864). Interacts with SLC25A23 (PubMed:24430870). Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2 (PubMed:26387864).

    Subcellular Location:
    Mitochondrion inner membrane; Single-pass membrane protein; Mitochondrion intermembrane space

    Tissue Specificity:
    Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.

    Similarity:
    Belongs to the MICU1 family. MICU1 subfamily.
    Contains 2 EF-hand domains.

    SWISS:
    Q9BPX6

    Gene ID:
    10367

    Database links:

    Entrez Gene: 507899 Cow

    Entrez Gene: 479241 Dog

    Entrez Gene: 10367 Human

    Entrez Gene: 216001 Mouse

    Entrez Gene: 365567 Rat

    Omim: 605084 Human

    SwissProt: Q0IIL1 Cow

    SwissProt: Q9BPX6 Human

    SwissProt: Q8VCX5 Mouse

    SwissProt: Q6P6Q9 Rat

    Unigene: 524367 Human

    Unigene: 27199 Mouse

    Unigene: 214252 Rat



    產(chǎn)品圖片
    Sample: Lane 1: A549 (Human) Cell Lysate at 30 ug Lane 2: U937 (Human) Cell Lysate at 30 ug Lane 3: U87MG (Human) Cell Lysate at 30 ug Lane 4: HepG2 (Human) Cell Lysate at 30 ug Primary: Anti- CBARA1/MICU1 (bsm-33198M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 54/46 kD Observed band size: 54/46 kD
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