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PCDH7 Rabbit pAb (bs-20154R)  
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50ul/1180.00元
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產品編號 bs-20154R
英文名稱 PCDH7 Rabbit pAb
中文名稱 原鈣粘蛋白7抗體
別    名 BH Pcdh; BH protocadherin; BH-Pcdh; BHPCDH; Brain heart protocadherin; Brain-heart protocadherin; PCDH 7; PCDH7; PCDH-7; PCDH7_HUMAN; Protocadherin 7; Protocadherin7; Protocadherin-7.  
研究領域 神經生物學  信號轉導  細胞粘附分子  細胞分化  細胞骨架  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Pig,Sheep,Cow)
產品應用 WB=1:500-2000,Flow-Cyt=2μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 113 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PCDH7: 31-130/1069 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 As a subfamily of the cadherin superfamily, protocadherins are cadherin-like cell adhesion proteins that contain up to seven extracellular domains and are predominantly expressed in the nervous system. Importantly, the adhesion mechanism of protocadherins is distinct from classic cadherins. Through inactivation or overexpression, several protocadherins have been implicated in a variety of cancers. PCDH7 (protocadherin 7), also known as BHPCDH or BH-Pcdh, is a 1069 amino acid single-pass I membrane protein that is expressed in the brain and heart. Containing seven cadherin domains, PCDH7 is thought to function in cell-cell recognition and adhesion. PCDH7 exists as three isoforms due to alternative splicing events.

Function:
Expressed predominantly in brain and heart and at lower levels in various other tissues.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Isoform C is phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 7 cadherin domains.

SWISS:
O60245

Gene ID:
5099

Database links:

Entrez Gene: 488843 Dog

Entrez Gene: 5099 Human

Entrez Gene: 54216 Mouse

Omim: 602988 Human

SwissProt: O60245 Human

Unigene: 479439 Human



產品圖片
Sample: K562(human)cell Lysate at 40 ug Primary: Anti-PCDH7 (bs-20154R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 113 kD Observed band size: 133 kD
Concebtration: 2ug/10^6 cells. Positive control: Mouse brain cells.
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