| 產(chǎn)品編號 | bs-19747R |
| 英文名稱 | Endophilin II Rabbit pAb |
| 中文名稱 | 胞吞蛋白Endophilin 2抗體 |
| 別 名 | SH3 containing Grb 2 like 1 protein; Endophilin II; CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 containing |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Endophilin II: 31-130/368 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Subcellular Location: Cytoplasm. Early endosome membrane. Associated with postsynaptic endosomes in hippocampal neurons. Tissue Specificity: Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. DISEASE: Note=In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene. Similarity: Belongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain. SWISS: Q99961 Gene ID: 6455 Database links: Entrez Gene: 6455 Human Entrez Gene: 20405 Mouse Omim: 601768 Human SwissProt: Q99961 Human SwissProt: Q62419 Mouse Unigene: 97616 Human Unigene: 1773 Mouse Unigene: 8762 Rat |
