| 產(chǎn)品編號 | bs-20055R |
| 英文名稱 | Rabbit Anti-CysLT2 antibody |
| 中文名稱 | 半胱氨酰白三烯受體2型抗體 |
| 別 名 | CLTR2_HUMAN; CYSLT2; CYSLT2R; CYSLTR 2; CysLTR2; Cysteinyl leukotriene CysLT2 receptor; Cysteinyl leukotriene receptor 2; G protein coupled receptor; G protein coupled receptor GPCR21; G protein coupled receptor HG57; G-protein coupled receptor GPCR21; G-protein coupled receptor HG57; GPCR; HG57; hGPCR21; HPN321; PSEC0146. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 40kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CysLT2: 2-100/346 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008] Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. Subcellular Location: Cell membrane. Tissue Specificity: Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q9NS75 Gene ID: 57105 Database links: Entrez Gene: 57105 Human Omim: 605666 Human SwissProt: Q9NS75 Human Unigene: 253706 Human Unigene: 614318 Human |
