| 產(chǎn)品編號 | bs-10926R |
| 英文名稱 | ARA9/XAP2 Rabbit pAb |
| 中文名稱 | 乙型肝炎病毒X相關(guān)蛋白2抗體 |
| 別 名 | AH receptor interacting protein; AH receptor-interacting protein; AIP; AIP; AIP_HUMAN; ARA 9; Aryl hydrocarbon receptor interacting protein; Aryl-hydrocarbon receptor-interacting protein; fa03h10; FKBP 16; FKBP 37; FKBP16; FKBP37; HBV X associated protein |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 38 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARA9: 1-100/330 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008] Function: signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein.May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) Subunit: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. Subcellular Location: Cytoplasm. Tissue Specificity: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver. DISEASE: Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA) [MIM:102200]. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma. Similarity: Contains 1 PPIase FKBP-type domain. Contains 2 TPR repeats. SWISS: O00170 Gene ID: 9049 Database links: Entrez Gene: 9049 Human Entrez Gene: 11632 Mouse Omim: 605555 Human SwissProt: O00170 Human SwissProt: O08915 Mouse Unigene: 20864 Dog Unigene: 412433 Human Unigene: 10433 Mouse Unigene: 95160 Rat |
