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Rabbit Anti-IL34  antibody (bs-18170R)  
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產(chǎn)品編號 bs-18170R
英文名稱 Rabbit Anti-IL34  antibody
中文名稱 白細胞介素34抗體
別    名 C16orf77; Chromosome 16 open reading frame 77; FPT025; IL 34; IL-34; IL34; IL34_HUMAN; Interleukin 34; Interleukin-34; Interleukin34; MGC34647.  
Specific References  (2)     |     bs-18170R has been referenced in 2 publications.
[IF=5.026] Qinghua Liu. et al. Inverse correlation between Interleukin-34 and gastric cancer, a potential biomarker for prognosis. Cell Biosci. 2020 Dec;10(1):1-13  IHC ;  
[IF=3.984] Liu, Kehui. et al. Combination of IL-34 and AFP improves the diagnostic value during the development of HBV related hepatocellular carcinoma. Clin Exp Med. 2022 Mar;:1-13  IHC ;  Human.  
研究領(lǐng)域 細胞生物  免疫學(xué)  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 25kDa
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL34: 21-100/242 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

Function:
Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.

Subcellular Location:
Secreted.

Tissue Specificity:
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Similarity:
Belongs to the IL-34 family.

SWISS:
Q8R1R4

Gene ID:
146433

Database links:

Entrez Gene: 146433 Human

Entrez Gene: 76527 Mouse

Entrez Gene: 498951 Rat

Omim: 612081 Human

SwissProt: Q6ZMJ4 Human

SwissProt: Q8R1R4 Mouse

SwissProt: Q4KM46 Rat

Unigene: 461214 Human

Unigene: 77697 Mouse

Unigene: 16799 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human intestine); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL34) Polyclonal Antibody, Unconjugated (bs-18170R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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