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Rabbit Anti-ATG14  antibody (bs-7462R)  
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產(chǎn)品編號 bs-7462R
英文名稱 Rabbit Anti-ATG14  antibody
中文名稱 自噬相關蛋白14抗體
別    名 4832427M01; ATG14; Atg14L; Autophagy-related protein 14-like protein; BAKOR_HUMAN; Barkor; Beclin 1-associated autophagy-related key regulator; D14Ertd114e; D14Ertd436e; KIAA0831; mCG_6911.  
Specific References  (1)     |     bs-7462R has been referenced in 1 publications.
[IF=9.584] Zheng, Bingxin. et al. Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway. CELL BIOSCI. 2022 Dec;12(1):1-15  WB ;  Human.  
研究領域 細胞生物  信號轉導  細胞凋亡  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Pig,Cow,Dog)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 55 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATG14: 41-140/492 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner.

Function:
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner.

Subunit:
Component of the autophagy-specific PI3-kinase complex I composed of ATG14, BECN1, PIK3C3 and PIK3R4, but not UVRAG, nor KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with PIK3CB (By similarity). Interacts with BECN1P1/BECN2.

Subcellular Location:
Cytoplasm. Endoplasmic reticulum. Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes.

Similarity:
Belongs to the Barkor family.

SWISS:
Q6ZNE5

Gene ID:
22863

Database links:

Entrez Gene: 22863 Human

Entrez Gene: 100504663 Mouse

Entrez Gene: 305831 Rat

Omim: 613515 Human

SwissProt: Q6ZNE5 Human

SwissProt: Q8CDJ3 Mouse

SwissProt: D4A4K3 Rat

Unigene: 414809 Human

Entrez Gene: 22863 Human

  • Entrez Gene: 100504663 Mouse
  • Entrez Gene: 305831 Rat
  • Omim: 613515 Human
  • SwissProt: Q6ZNE5 Hun
  • SwissProt: Q8CDJ3 MouseSwissProt: D4A4K3 Rat
  • Unigene: 414809 Human


  • 產(chǎn)品圖片
    Sample: Lane 1: Human MCF-7 cell lysates Lane 2: Human SH-SY5Y cell lysates Lane 3: Human HeLa cell lysates Lane 4: Human A549 cell lysates Lane 5: Human A431 cell lysates Primary: Anti-ATG14 (bs-7462R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kDa Observed band size: 68 kDa
    Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ATG14) Polyclonal Antibody, Unconjugated (bs-7462R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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