| 產(chǎn)品編號 | bs-16219R |
| 英文名稱 | GALNT3 Rabbit pAb |
| 中文名稱 | GALNT3蛋白抗體 |
| 別 名 | DKFZp686C10199; EC 2.4.1.41; GalNAc T3; GalNAc transferase 3; GalNAc-T3; GalNAcT3; GALNT3; GALT3_HUMAN; HFTC; HHS; MGC61909; OTTHUMP00000204915; OTTHUMP00000204919; Polypeptide GalNAc transferase 3; Polypeptide N acetylgalactosaminyltransferase 3; Polypep |
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Specific References (1) | bs-16219R has been referenced in 1 publications.
[IF=2.559] Wang?B et al. GALNT3 inhibits NF-κB signaling during influenza A virus infection. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2872-2877. WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 細胞類型標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 73 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GALNT3: 1-100/633 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008] Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. Subcellular Location: Golgi apparatus; Golgi stack membrane. Resides preferentially in the trans and medial parts of the Golgi stack. DISEASE: Defects in GALNT3 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Contains 1 ricin B-type lectin domain. SWISS: Q14435 Gene ID: 2591 Database links: Entrez Gene: 2591 Human Omim: 601756 Human SwissProt: Q14435 Human Unigene: 170986 Human |
