| 產(chǎn)品編號(hào) | bs-16156R |
| 英文名稱 | FNBP4 Rabbit pAb |
| 中文名稱 | FNBP4蛋白抗體 |
| 別 名 | DKFZp779I1064; FBP30; FNBP4_HUMAN; FLJ41904; FNBP 4; Formin binding protein 30; Formin binding protein 4; KIAA1014. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 結(jié)合蛋白 細(xì)胞骨架 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 110 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FNBP4: 921-1017/1017 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FNBP4 is a 1,017 amino acid protein that contains two WW domains and binds to the Arg/Gly-rich-flanked Pro-rich domains of Formin 1, possibly regulating Formin 1 function. In response to DNA damage, FNBP4 is subject to post-translational phosphorylation, probably by ATM or ATR. The gene encoding FNBP4 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. Function: FNBP4 (Formin binding protein 4) binds FMN1. It contains 2 WW domains which interact with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding. Similarity: Contains 2 WW domains. SWISS: Q8N3X1 Gene ID: 23360 Database links: Entrez Gene: 23360 Human Entrez Gene: 55935 Mouse SwissProt: Q8N3X1 Human SwissProt: Q6ZQ03 Mouse |
