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Rabbit Anti-GALNT14  antibody (bs-11018R)  
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產(chǎn)品編號 bs-11018R
英文名稱 Rabbit Anti-GALNT14  antibody
中文名稱 GalNAc-T14抗體
別    名 GalNAc T14; GalNAc-T14; Galnt14; GALNT14; GalNac-T10; GALNT15; pp-GaNTase 14; GLT14_HUMAN; Polypeptide GalNAc transferase 14; Polypeptide N acetylgalactosaminyltransferase 14; Polypeptide N-acetylgalactosaminyltransferase 14; pp GaNTase 14; Protein UDP acetylgalactosaminyltransferase 14; Protein-UDP acetylgalactosaminyltransferase 14; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 14; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14.   
Specific References  (2)     |     bs-11018R has been referenced in 2 publications.
[IF=3.071] Shan et al. GALNT14 Involves the Regulation of Multidrug Resistance in Breast Cancer Cells. (2018) Transl.Oncol. 11:786-793  IHC ;  Human.  
[IF=2.33] Yang, Juan, Guiyuan Li, and Keqiang Zhang. "Pro-survival effects by NF-κB, Akt and ERK (1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer." Biomedicine & Pharmacotherapy 84 (2016): 1078-1087.  WB ;  Human.  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  通道蛋白  細胞類型標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 64kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GALNT14: 101-200/552 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.

Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein.

Tissue Specificity:
Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus.

Similarity:
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Contains 1 ricin B-type lectin domain.

SWISS:
Q96FL9

Gene ID:
79623

Database links:

Entrez Gene: 79623 Human

Entrez Gene: 71685 Mouse

Entrez Gene: 313878 Rat

Omim: 608225 Human

SwissProt: Q96FL9 Human

SwissProt: Q8BVG5 Mouse

Unigene: 468058 Human

Unigene: 271953 Mouse

Unigene: 24642 Rat



產(chǎn)品圖片
Sample: A549(Human) Cell Lysate at 30 ug MG63(Human) Cell Lysate at 30 ug Primary: Anti- GALNT14 (bs-11018R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 64 kD Observed band size: 66 kD
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