| 產(chǎn)品編號 | bs-13160R |
| 英文名稱 | Fibulin 2 Rabbit pAb |
| 中文名稱 | 纖連蛋白2抗體 |
| 別 名 | Fibulin-2; Fbln2; FBLN2_HUMAN; FIBL-2; Fibulin-2; OTTHUMP00000216670; OTTHUMP00000216671; OTTHUMP00000216672. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 124 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fibulin 2: 501-600/1184 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Fibulin-1 and Fibulin-2 associate with Fibronectin and other extracellular matrix proteins. In bone marrow, Fibulin-1 and Fibulin-2 bind to Fibronectin in the adherent layer. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and as an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. The mobility of cancer cells may be inhibited with increasing exposure to Fibulin-1. Fibulin-2 binds to the lectin domains of extracellular matrix proteins aggrecan, versican and brevican. Fibulin-2 is abundantly expressed in heart, placenta and ovarian tissue, where it localizes to basement membranes and connective tissue compartments. In mice, differential Fibulin-2 gene expression correlates with the early phase of diabetic kidneys and glomerulosclerosis. The gene encoding human Fibulin-2 maps to chromosome 3p25.1. Function: Its binding to fibronectin and some other ligands is calcium dependent. Subunit: Homotrimer; disulfide-linked. Interacts with LAMA2 (By similarity). Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary. Post-translational modifications: O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348. Similarity: Belongs to the fibulin family. Contains 3 anaphylatoxin-like domains. Contains 11 EGF-like domains. SWISS: P98095 Gene ID: 2199 Database links: Entrez Gene: 2199 Human Entrez Gene: 14115 Mouse Omim: 135821 Human SwissProt: P98095 Human SwissProt: P37889 Mouse Unigene: 198862 Human Unigene: 249146 Mouse Unigene: 410235 Mouse |
