| 產(chǎn)品編號 | bs-12996R |
| 英文名稱 | Dermcidin Rabbit pAb |
| 中文名稱 | 抗菌蛋白DCD抗體 |
| 別 名 | AIDD; DCD 1; dcd; DCD-1; DCD_HUMAN; DSEP; HCAP; PIF; Preproteolysin; Dermcidin. |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)菌及病毒 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 11 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dermcidin/DCD: 63-109/110 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Antimicrobial peptides participate in the innate response, which may provide a barrier for protection against infection. The Dermcidin gene encodes an antimicrobial peptide DCD-1, which is constitutively expressed in sweat glands, secreted into the sweat, and transported to the epidermal surface. DCD-1 displays antimicrobial activity in response to a variety of pathogenic microorganisms. Overexpression of Dermcidin in breast cancers promotes cell growth and survival, and is coupled with a focal copy number gain of its locus on human chromosome 12q13.2. Function: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. Subcellular Location: Secreted. Tissue Specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml. SWISS: P81605 Gene ID: 117159 Database links: Entrez Gene: 117159 Human Omim: 606634 Human SwissProt: P81605 Human Unigene: 350570 Human 人源性多肽Dermcidin(DCD)是最近從人體汗液中分離出來的一種天然活性多肽,其編碼基因dermcidin最初被認(rèn)為在汗腺中特異性表達(dá),并且與其他已知的編碼基因沒有同源性。DCD在外泌汗腺中組成性表達(dá)并分泌到汗液中,其衍生物DCD-1L和DCD-1在較廣的pH范圍和高鹽濃度下具有抗部分細(xì)菌和真菌的活性。經(jīng)證實,以前在人類神經(jīng)細(xì)胞中發(fā)現(xiàn)的一種存活促進(jìn)肽以及人體內(nèi)與一種鼠惡病質(zhì)因子同源的多肽均屬于DCD衍生物。最新研究發(fā)現(xiàn)dermcidin基因在人乳腺癌等腫瘤細(xì)胞及肝細(xì)胞中可能作為潛在的致癌基因而存在。不僅如此,人們在人類胎盤組織中也發(fā)現(xiàn)了dermcidin基因的表達(dá)并分離出了DCD。所以,DCD可能作為多功能的活性多肽在腫瘤發(fā)生及人體天然免疫系統(tǒng)疾病、神經(jīng)系統(tǒng)疾病、妊娠相關(guān)疾病的病理生理過程中發(fā)揮作用。在感染性疾病和炎癥上將來有著廣泛應(yīng)用的可能。 |
