| 產(chǎn)品編號 | bs-12257R |
| 英文名稱 | phospho-CXCR2 (Ser347) Rabbit pAb |
| 中文名稱 | 磷酸化細(xì)胞表面趨化因子受體2抗體 |
| 別 名 | CXCR2(phospho S347); CXCR2(phospho Ser347); p-CXCR2(phospho S347); p-CD182(phospho Ser347); CXC-chemokine receptor 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine(CXC) receptor 2; CMKAR2; CXCR 2; CXC R2; CXC-R2; CXCR2_HUMAN; C-X-C chemokine receptor t |
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Specific References (1) | bs-12257R has been referenced in 1 publications.
[IF=3.098] Rui Zou. et al. Role of integrin?linked kinase in static compressive stress?induced autophagy via phosphatidylinositol?3 kinase in human periodontal ligament cells. Int J Mol Med. 2021 Sep;48(3):1-11 WB ; Human.
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| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser347: RP(p-S)FV |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]. Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylated upon ligand binding; which is required for desensitization. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25025 Gene ID: 3579 Database links: Entrez Gene: 3579 Human Entrez Gene: 12765 Mouse Omim: 146928 Human SwissProt: P25025 Human SwissProt: P35343 Mouse |
| 產(chǎn)品圖片 |
Sample:
Bone (Mouse) Lysate at 40 ug
Primary: Anti-phospho-CXCR2 (Ser347) (bs-12257R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 51 kD
Sample:
Lane 1: HL60 (Human) Cell Lysate at 30 ug
Lane 2: Skin (Mouse) Lysate at 40 ug
Primary:
Anti-phospho-CXCR2 (Ser347) (bs-12257R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45/55 kD
Observed band size: 48 kD
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