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Rabbit Anti-Mitoferrin 2/SLC25A28  antibody (bs-7157R)  
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產(chǎn)品編號(hào) bs-7157R
英文名稱 Rabbit Anti-Mitoferrin 2/SLC25A28  antibody
中文名稱 線粒體鐵轉(zhuǎn)運(yùn)蛋白2抗體
別    名 MFRN2; Mitochondrial iron transporter 2; Mitochondrial RNA splicing protein 3/4; Mitoferrin 2; Mitoferrin2; Mitoferrin-2; MRS3/4; MRS4L; NPD016; Putative mitochondrial solute carrier; MFRN2_HUMAN; SLC25A28.  
Specific References  (3)     |     bs-7157R has been referenced in 3 publications.
[IF=6.312] Christine Fischer. et al. Dietary Iron Overload and Hfe?/? Related Hemochromatosis Alter Hepatic Mitochondrial Function. Antioxidants-Basel. 2021 Nov;10(11):1818  WB ;  Mouse.  
[IF=6.117] Jingjing Liu. et al. Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction. J NUTR BIOCHEM. 2022 Dec;:109258  WB ;  Mouse, Human.  
[IF=3.383] Dongchen Wang. et al. Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis. Exp Cell Res. 2021 May;402:112552  IF ;  Mouse.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Pig,Sheep,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39kDa
細(xì)胞定位 細(xì)胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Mitoferrin 2: 271-364/364 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Mitoferrin 2, also known as MRS3/4 (mitochondrial RNA-splicing protein 3/4 homolog), mitochondrial iron transporter 2, NPD016, MRS4L or SLC25A28 (solute carrier family 25 member 28), is a 364 amino acid multi-pass membrane protein of the mitochondrial inner membrane that mediates iron uptake. Mitoferrin 2 is thought to play a role in heme synthesis of hemoproteins and iron-sulfur cluster assembly. Ubiquitously expressed, Mitoferrin 2 is found at high levels in skeletal muscle, heart, placenta, kidney, lung, liver, brain and pancreas. Mitoferrin 2 is a member of the mitochondrial carrier family and undergoes alternative splicing events to produce four isoforms. Mitoferrin 2 contains three solcar repeats and is encoded by a gene that maps to human chromosome 10q24.2.

Function:
SLC25A28 is a mitochondrial iron transporter that mediates iron uptake. It is probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells.

Subcellular Location:
Mitochondrion inner membrane; Multi pass membrane protein. Note: Isoform 1 and isoform 2 are both localized in the mitochondrion.

Tissue Specificity:
Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart.

Similarity:
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Contains 3 Solcar repeats.

SWISS:
Q96A46

Gene ID:
81894

Database links:

Entrez Gene: 538529 Cow

Entrez Gene: 486837 Dog

Entrez Gene: 81894 Human

Entrez Gene: 246696 Mouse

Entrez Gene: 688811 Rat

Omim: 609767 Human

SwissProt: Q96A46 Human

SwissProt: Q8R0Z5 Mouse

SwissProt: B2RYH0 Rat



產(chǎn)品圖片
Sample: Lane 1: Liver (Mouse) Lysate at 40 ug Lane 2: Liver (Rat) Lysate at 40 ug Lane 3: Heart (Rat) Lysate at 40 ug Primary: Anti-Mitoferrin 2/SLC25A28 (bs-7157R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 37 kD
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