| 產(chǎn)品編號 | bs-11630R |
| 英文名稱 | Rabbit Anti-HCN2 + HCN4 antibody |
| 中文名稱 | 環(huán)化核苷酸調(diào)控陽離子通道蛋白亞型2/4抗體 |
| 別 名 | HCN2+HCN4; HCN2 / HCN4; HCN2+4; HCN2/4; BCNG 2; Brain cyclic nucleotide gated channel 2; HAC 1; HCN 4; HCN 2; Hyperpolarization activated cyclic nucleotide gated potassium channel 4;HCN2_HUMAN; HCN4_HUMAN. |
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Specific References (1) | bs-11630R has been referenced in 1 publications.
[IF=1.468] Fei-Fei Wang. et al. Aging-induced atrial fibrosis in If current change and its effect on atrial fibrillation in dogs. ANN NONINVAS ELECTRO. 2022 Apr 11 WB ; Mouse.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Chicken) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HCN2 + HCN4: 151-250/889 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Hyperpolarization activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node. Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2 Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Highly expressed throughout the brain. Detected at low levels in heart. Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. SWISS: Q9UL51 Gene ID: 610 Database links: Entrez Gene: 10021 Human Entrez Gene: 610 Human Entrez Gene: 15166 Mouse Entrez Gene: 330953 Mouse Omim: 602781 Human Omim: 605206 Human SwissProt: Q9UL51 Human SwissProt: Q9Y3Q4 Human SwissProt: O70507 Mouse SwissProt: O88703 Mouse |
| 產(chǎn)品圖片 |
Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Cerebral cortex (Mouse) Lysate at 40 ug
Primary: Anti- HCN2 + HCN4 (bs-11630R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 97/129 kD
Observed band size: 97 kD
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