| 產(chǎn)品編號 | bs-11436R |
| 英文名稱 | Rabbit Anti-SLCO1C1 antibody |
| 中文名稱 | 溶質(zhì)載體家族蛋白21成員1C1抗體 |
| 別 名 | OATP-F; OATP1C1; OATPRP5; OATP14; organic anion transporter F; organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; SLC21A14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family, member 1C1; SO1C1_HUMAN . |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 通道蛋白 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 79kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLCO1C1/OATP-F: 401-500/712 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain. Function: SLCO1C1 is a member of the organic anion transporter family. SLCO1C1 is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants which produce 5 distinct proteins. Subcellular Location: Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus Tissue Specificity: Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels. Similarity: Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain. SWISS: Q9NYB5 Gene ID: 53919 Database links: Entrez Gene: 53919 Human Entrez Gene: 58807 Mouse Omim: 613389 Human SwissProt: Q9NYB5 Human SwissProt: Q9ERB5 Mouse Unigene: 47261 Human Unigene: 284495 Mouse Unigene: 45744 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Hela (Human) Cell Lysate at 30 ug
Lane 2: SH-SY5Y (Human) Cell Lysate at 30 ug
Primary:
Anti- SLCO1C1 (bs-11436R) at 1/1000 dilution
Anti-beta-Actin (bs-0061R) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 79 kD
Observed band size: 76 kD
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