| 產(chǎn)品編號(hào) | bs-8650R |
| 英文名稱 | Rabbit Anti-T2R38 antibody |
| 中文名稱 | 味覺(jué)感受器蛋白T2R38抗體 |
| 別 名 | PTC; PTC bitter taste receptor; TAS2R38; T2R38; T2R61; taste receptor, type 2, member 38; T2R38_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 通道蛋白 G蛋白偶聯(lián)受體 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Chicken) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 38 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human T2R38/TAS2R38: 151-250/333 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting. Function: TAS2R38 is gustducin-linked and may play a role in the perception of bitterness and in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Similarity: Belongs to the G-protein coupled receptor T2R family. SWISS: P59533 Gene ID: 5726 Database links: Entrez Gene: 5726 Human Omim: 607751 Human SwissProt: P59533 Human Unigene: 647085 Human TAS2R38是一種苦味味覺(jué)感受器，該感受器可以嘗出苯硫脲和丙硫氧嘧啶或者相關(guān)物質(zhì)的苦味。這一點(diǎn)和大多數(shù)苦味感受器有所不同，即該感受器是對(duì)某類物質(zhì)敏感，而大多數(shù)感受器則不會(huì)表現(xiàn)出強(qiáng)烈的選擇性，能對(duì)多種物質(zhì)做出響應(yīng)。該感受器所能嘗出的相應(yīng)物質(zhì)大量存在于西蘭花、卷心菜以及其它十字花科植物中，例如：葡萄糖異硫氰酸鹽及其相關(guān)產(chǎn)物異硫氰酸酯。目前全球人類中，約有75%該感受器相關(guān)基因正常，即，可以嘗出苦味。而剩下的25%則無(wú)法嘗出這類的苦味，或者敏感度較低。 |
