| 產(chǎn)品編號(hào) | bs-9716R |
| 英文名稱 | Rabbit Anti-KBP antibody |
| 中文名稱 | KBP蛋白抗體 |
| 別 名 | Hypothetical protein LOC26128; KBP; KBP_HUMAN; KIAA1279; KIF1-binding protein; TTC20; Uncharacterized protein KIAA1279. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 細(xì)胞分化 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 72kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KBP: 151-250/621 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Chromosome 10 contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious. The KIAA1279 gene product has been provisionally designated KIAA1279 pending further characterization. Function: Required for organization of axonal microtubules, andaxonal outgrowth and maintenance during peripheral and centralnervous system development. Regulates mitochondrial transport bymodulating KIF1B motor activity. Subunit: Interacts with KIF1B. Subcellular Location: Mitochondrion. Tissue Specificity: Highly expressed in heart, brain, ovary, testis, spinal cord and all specific brain regions examined. Moderate expressed at intermediate level in all other adult tissues examined, as well as in fetal liver and brain. Not expressed in blood leukocytes. DISEASE: Defects in KIAA1279 are the cause of Goldberg-Shprintzenmegacolon syndrome (GOSHS) [MIM:609460]. GOSHS is characterized bymicrocephaly, mental retardation and facial dysmorphism, as well asphenotypes related to Hirschsprung disease syndrome. Similarity: Belongs to the KIF1-binding protein family. SWISS: Q96EK5 Gene ID: 26128 Database links: Entrez Gene: 100063227 Horse Entrez Gene: 26128 Human Entrez Gene: 72320 Mouse Omim: 609367 Human SwissProt: Q96EK5 Human SwissProt: Q6ZPU9 Mouse Unigene: 279580 Human Unigene: 258955 Mouse Unigene: 100975 Rat |
| 產(chǎn)品圖片 |
Sample: Hela Cell (Human) Lysate at 30 ug
Primary: Anti-KBP (bs-9716R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 72kD
Observed band size: 75kD
Sample: Raji Cell (Human) Lysate at 30 ug
Primary: Anti-KBP (bs-9716R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 72kD
Observed band size: 75kD
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