| 產(chǎn)品編號 | bs-9209R |
| 英文名稱 | Rabbit Anti-SERPINA10 antibody |
| 中文名稱 | 絲氨酸蛋白酶抑制劑A10抗體 |
| 別 名 | Protein Z dependent protease inhibitor; Protein Z dependent protease inhibitor precursor; Protein Z-dependent protease inhibitor; PZ dependent protease inhibitor; PZ-dependent protease inhibitor; PZI; serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 10 ; Serpin A10; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 10; SERPINA 10; SERPINA10; ZPI; ZPI_HUMAN. |
| 研究領(lǐng)域 | 心血管 細胞生物 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 48kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZPI/SERPINA10: 251-350/444 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ZPI, also known as SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10) or PZI, is a 444 amino acid secreted protein that functions as a Protein Z-dependent protease inhibitor. Expressed by the liver, ZPI is secreted into the plasma where, in the presence of calcium, Protein Z and phospholipids, it inhibits the activated pro-coagulation factors X and XI (Factor X and Factor XI). This inhibition helps properly regulate intravenous blood clotting. ZPI, a member of the serpin protein family, contains five potential N-linked glycosylation sites and a tyrosine at position 387 which, when disrupted, renders ZPI inactive. Defects in the gene encoding ZPI may increase susceptibility to venous thrombosis, the formation of blood clots within a vein. Function: Inhibits factor Xa activity in the presence of protein Z, calcium and phospholipid. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted in plasma. Post-translational modifications: Phosphorylation sites are present in the extracelllular medium. Similarity: Belongs to the serpin family. SWISS: Q9UK55 Gene ID: 51156 Database links: Entrez Gene: 51156 Human Omim: 605271 Human SwissProt: Q9UK55 Human Unigene: 118620 Human |
