| 產(chǎn)品編號 | bs-7510R |
| 英文名稱 | stabilin1 Rabbit pAb |
| 中文名稱 | 淋巴管內(nèi)皮細(xì)胞和血管內(nèi)皮細(xì)胞受體1抗體 |
| 別 名 | CLEVER 1; Common lymphatic endothelial and vascular endothelial receptor 1; Fasciclin EGF like laminin type EGF like and link domain containing scavenger receptor 1; fasciclin egf-like; FEEL 1; FELE 1; FEX1; KIAA0246; MS 1 antigen; STAB1; STAB-1; STAB 1; |
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Specific References (2) | bs-7510R has been referenced in 2 publications.
[IF=3.078] Simon Harper. et al. Portal venous repopulation of decellularised rat liver scaffolds with syngeneic bone marrow stem cells. J Tissue Eng Regen M. 2020 Oct;14(10):1502-1512 IF ; Rat.
[IF=2.676] Yohei Ikezumi. et al. Steroid treatment promotes an M2 anti-inflammatory macrophage phenotype in childhood lupus nephritis. Pediatr Nephrol. 2021 Feb;36(2):349-359 IF ; Human.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 生長因子和激素 血管內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 273 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human stabilin1: 1201-1400/2570 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Stabilin-1 is a large transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. Subunit: Interacts with CHID1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells. Similarity: Contains 16 EGF-like domains. Contains 7 FAS1 domains. Contains 2 laminin EGF-like domains. Contains 1 Link domain. SWISS: Q9NY15 Gene ID: 23166 Database links: Entrez Gene: 23166 Human Omim: 608560 Human SwissProt: Q9NY15 Human Unigene: 301989 Human |
