| 產(chǎn)品編號 | bs-6812R |
| 英文名稱 | Rabbit Anti-FMNL1 antibody |
| 中文名稱 | 成蛋白相關(guān)蛋白1抗體 |
| 別 名 | C17orf1; C17orf1B; CLL associated antigen KW 13; FHOD4; FMNL; Fnrl; Formin like 1; Formin like; Formin related protein; Frls; KW 13; KW13; Leukocyte formin; MGC133052; MGC1894; MGC21878; FMNL_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 122kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FMNL1: 831-930/1100 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FMNL1 (Formin-like protein 1) gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cyokinesis, and cell polarity. An alternative splice variant has been described but the full length sequence has not yet been determined. FMNL1 possibly has a role in the control of cell motility and survival of macrophages. Function: May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Subunit: Interacts with RAC1, PFN1 and PFN2.Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1. Subcellular Location: Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1. Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions. Tissue Specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Post-translational modifications: Myristoylation mediates membrane localization and blebbing. Similarity: Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. SWISS: O95466 Gene ID: 752 Database links: Entrez Gene: 752 Human Entrez Gene: 57778 Mouse Omim: 604656 Human SwissProt: O95466 Human SwissProt: Q9JL26 Mouse Unigene: 100217 Human Unigene: 138913 Mouse |
