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Rabbit Anti-ZDHHC17  antibody (bs-6628R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-6628R
英文名稱 Rabbit Anti-ZDHHC17  antibody
中文名稱 NFκB激活蛋白205抗體
別    名 HSPC294; Putative MAPK activating protein PM11; Putative NF kappa B activating protein 205; Zinc finger DHHC domain containing protein 17; DHHC domain containing 17; HIP14; HIP3; huntingtin interacting protein 14; huntingtin interacting protein 3; Huntingtin interacting protein H; HYPH; KIAA0946; ZDHHC 17; zinc finger; ZDH17_HUMAN.  
研究領域 神經(jīng)生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 73kDa
細胞定位 細胞漿 細胞膜 細胞外基質 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZDHHC17: 365-460/632 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 ZDHHC17 is a neuronal palmitoyl transferase. Palmitoylation is critical for trafficking and function of signaling molecules, neurotransmitter receptors, and synaptic scaffolding proteins in neurons. ZDHHC17 causes cellular transformation. It has been shown that mRNA encoding ZDHHC17 is up-regulated in a number of types of human tumors, thus ZDHHC17 and other PATs (palmitoyl acyltransferases) are potential targets for new anticancer drugs.

Function:
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport.

Subunit:
Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.

Subcellular Location:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.

Tissue Specificity:
Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.

Post-translational modifications:
Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.

Similarity:
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Contains 5 ANK repeats.
Contains 1 DHHC-type zinc finger.

SWISS:
Q8IUH5

Gene ID:
23390

Database links:

Entrez Gene: 23390 Human

Entrez Gene: 320150 Mouse

Entrez Gene: 366889 Rat

Omim: 607799 Human

SwissProt: Q8IUH5 Human

SwissProt: Q80TN5 Mouse

Unigene: 4014 Human

Unigene: 339281 Mouse



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