| 產(chǎn)品編號(hào) | bs-6117R |
| 英文名稱 | Tomoregulin-1 Rabbit pAb |
| 中文名稱 | 腦腫瘤抑癌蛋白1抗體 |
| 別 名 | Tomoregulin1; Tomoregulin 1; C9orf2; H 7365; H7365; TEFF 1; TEFF1; TMEFF 1; TMEFF1; TR 1; TR1; Transmembrane protein with EGF like and two follistatin like domains 1; TEFF1_HUMAN. |
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Specific References (1) | bs-6117R has been referenced in 1 publications.
[IF=5] Bao, Dan, et al. "Tomoregulin-1 inhibits cardiac hypertrophy after pressure overload via TAK1-JNK pathways in mice." Disease Models & Mechanisms(2015): dmm-021303. IHC-F ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 37 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tomoregulin-1: 65-160/380 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Tomoregulin-1 precursor is a single-pass type I membrane protein thought to be a tumor suppressor in brain cancers. Its expression is down-regulated in these tumors as compared to control brain tissues. In addition, it might also inhibit NODAL and BMP signaling during neural patterning. There are 2 isoforms produced by alternative splicing. Function: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. Subunit: May interact with ST14. Subcellular Location: Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Tissue Specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. Similarity: Belongs to the tomoregulin family. Contains 1 EGF-like domain. Contains 2 Kazal-like domains. SWISS: Q8IYR6 Gene ID: 8577 Database links: Entrez Gene: 100526694 Human Entrez Gene: 8577 Human Entrez Gene: 230157 Mouse Omim: 603421 Human SwissProt: Q8IYR6 Human SwissProt: Q6PFE7 Mouse Unigene: 598100 Human Unigene: 422686 Mouse Unigene: 162809 Rat |
