| 產(chǎn)品編號(hào) | bs-3932R |
| 英文名稱 | CACH3 Rabbit pAb |
| 中文名稱 | L型鈣通道蛋白a1亞型3抗體 |
| 別 名 | CACH3; CACN4; CACNA 1D; CACNA1D; CACNL1A2; Calcium channel L type alpha 1 polypeptide isoform 2; Calcium channel neuroendocrine/brain type alpha 1 subunit; Calcium channel voltage dependent L type alpha 1D subunit; CCHL1A2; Voltage dependent L type calcium channel subunit alpha 1D; Voltage gated calcium channel alpha 1 subunit; Voltage gated calcium channel alpha subunit Cav1.3; Voltage gated calcium channel subunit alpha Cav1.3; CAC1D_HUMAN. |
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Specific References (1) | bs-3932R has been referenced in 1 publications.
[IF=3.2] Lobeck, Inna, et al. "Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes." Virology 499 (2016): 185-195. IF(ICC) ; Monkey.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 245 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CaV13: 1201-1300/2161 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Subunit: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner (By similarity). Interacts with RIMBP2 (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. Similarity: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. SWISS: Q01668 Gene ID: 776 Database links: Entrez Gene: 776 Human Entrez Gene: 12289 Mouse Omim: 114206 Human SwissProt: Q01668 Human SwissProt: Q99246 Mouse Unigene: 476358 Human Unigene: 9772 Mouse Unigene: 89671 Rat |
