| 產(chǎn)品編號 | bs-3790R |
| 英文名稱 | Rabbit Anti-GM-CSF antibody |
| 中文名稱 | 粒細(xì)胞-巨噬細(xì)胞克隆刺激因子抗體 |
| 別 名 | Granulocyte-Macrophage Colony Stimulating Factor; Burst Promoting Activity; CMCSF; Colony Stimulating Factor 2; Colony stimulating factor; CSF 2; CSF Alpha; CSF; CSF2; Eosinophil Colony Stimulating Factor; GMCSF; Granulocyte Macrophage Colony Stimulating Factor; MGC131935; MGC138897; Molgramostin; Pluripoietin Alpha; Sargramostim; granulocyte-macrophage colony-stimulating factor precursor; CSF2_HUMAN. |
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Specific References (6) | bs-3790R has been referenced in 6 publications.
[IF=19.572] Hilgendorf et al. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. (2014) Circulatio. 129:1677-87 IHC-P ; Human.
[IF=11] Anzai, Atsushi, et al. "The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes." Journal of Experimental Medicine (2017): jem-20170689. IHC-P ; Mouse.
[IF=10.79] Anzai et al. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. (2017) J.Exp.Med. 214:3293-3310 IHC-P ; Mouse.
[IF=6.129] Papp KA et al. GM-CSF as a therapeutic target in psoriasis: randomised, controlled investigation using namilumab - a specific, human anti-GM-CSF monoclonal antibody.(2018) Br. J. Dermatol. Sep 12 Human.
[IF=5.875] Yuan SJ. et al. Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.. Int J Pharmaceut. 2021 Jul;606:120872-120872 IHC ; Mouse.
[IF=0.3] Li, Zhen, et al. "Methods for transferring gene into silkworm and expression of hGM-CSF in silk glands of transgenic silkworm." Journal of Chemical and Pharmaceutical Research 6.5 (2014): 118-129. WB ;
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 趨化因子 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Pig (predicted: Human,Mouse,Rat,Rabbit,Cow,Chicken,Dog,Recombinant protein) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 14kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GM-CSF: 65-144/144 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]. Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Subunit: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Subcellular Location: Secreted. Similarity: Belongs to the GM-CSF family. SWISS: P04141 Gene ID: 1437 Database links: Entrez Gene: 1437 Human Omim: 138960 Human SwissProt: P04141 Human GM-CSF是血管內(nèi)皮細(xì)胞、單核細(xì)胞和成纖維細(xì)胞合成的糖蛋白。能促進(jìn)中性粒細(xì)胞成熟；刺激成熟的粒細(xì)胞從骨髓釋出；增強(qiáng)中性粒細(xì)胞趨化及吞噬功能。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Recombined Trx/His-tag porcine?GM-CSF protein (Aa18-144) at 2 ug
Lane 2: Recombined?His-tag?porcine?GM-CSF protein
Primary: Anti-GM-CSF (bs-3790R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 33/15 kD
Observed band size: 33/15 kD
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