| 產(chǎn)品編號(hào) | bs-3651R |
| 英文名稱 | F11R/JAM-A/CD321 Rabbit pAb |
| 中文名稱 | 連接粘附分子1抗體 |
| 別 名 | JAM1_HUMAN; Junctional adhesion molecule A; Junctional adhesion molecule 1(JAM-1); Platelet F11 receptor; Platelet adhesion molecule 1(PAM-1); JAM1; JAM 1; JAM A; JCAM; JAM; KAT; JAMA; PAM-1; UNQ264/PRO301; CD 321; CD-321; CD321 antigen; F11 receptor; |
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Specific References (2) | bs-3651R has been referenced in 2 publications.
[IF=3.775] Xue Y et al. Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague–Dawley rats. Food Chem Toxicol. 2019 Aug 4;133:110751. WB ; Rat.
[IF=3.114] Yugo Kato. et al. Tocotrienols reach the brain and play roles in the attenuation of body weight gain and improvement of cognitive function in high-fat diet-treated mice. 2021 Jun 11 WB ; Mouse.
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| 研究領(lǐng)域 | 心血管 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 細(xì)胞粘附分子 細(xì)胞骨架 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 30 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Junctional Adhesion Molecule 1: 51-150/299 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Junctional Adhesion Molecule 1 (JAM1) seems to play a role in epithelial tight junction formation. It appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. JAM1 plays a role in regulating monocyte transmigration involved in integrity of the epithelial barrier. JAM1 is also involved in platelet activation. Function: Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Subunit: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity). Subcellular Location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Post-translational modifications: N-glycosylated. Similarity: Belongs to the immunoglobulin superfamily. Contains 2 Ig-like V-type (immunoglobulin-like) domains. SWISS: Q9Y624 Gene ID: 50848 Database links: Entrez Gene: 50848 Human Entrez Gene: 16456 Mouse Omim: 605721 Human SwissProt: Q9Y624 Human SwissProt: O88792 Mouse Unigene: 517293 Human Unigene: 294882 Mouse |
