mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
欧美日韩精品系列一区二区,日本成人精品视频在线
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Rabbit Anti-SHIP1  antibody (bs-3567R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@m.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@m.p2b3.cn
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-3567R
英文名稱 Rabbit Anti-SHIP1  antibody
中文名稱 SH2結(jié)構(gòu)含磷酸肌醇SHIP1抗體
別    名 Inositol polyphosphate 5 phosphatase of 145kDa; 4; 5-trisphosphate 5-phosphatase 1; hp51CN; hSHIP; Inositol polyphosphate 5 phosphatase 145kDa; Inositol polyphosphate 5 phosphatase; Inositol polyphosphate 5 phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; INPP 5D; INPP5D; INPP5D protein; MGC104855; MGC142140; MGC142142; p150 ship; p150Ship; Phosphatidylinositol 3, 4, 5 trisphosphate 5 phosphatase 1; Phosphatidylinositol-3; SH2 containing inositol 5 phosphatase; SH2 containing inositol phosphatase isoform b; SH2 domain containing inositol 5' phosphatase 1; SH2 domain containing inositol phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5''-phosphatase 1; SHIP 1; SHIP-1; SHIP1; SHIP1_HUMAN; Signaling inositol polyphosphate 5 phosphatase SIP 145; Signaling inositol polyphosphate 5 phosphatase SIP145; SIP 145; SIP-145; SIP145.  
Specific References  (2)     |     bs-3567R has been referenced in 2 publications.
[IF=6.376] Wang, Wenxin. et al. Preparation of a miR-155-activating nucleic acid nanoflower to study the molecular mechanism of miR-155 in inflammation. MOL MED. 2022 Dec;28(1):1-17  WB ;  Human.  
[IF=4.784] Wan B et al. Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction. Int J Biol Macromol. 2019 Jul 5;138:198-206.  WB ;  Monkey.  
研究領(lǐng)域 免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Pig,Cow,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 133 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHIP1: 701-800/1189 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

Function:
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Subunit:
Interacts with tyrosine phosphorylated forms of SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150. Interacts with PTPN11 in response to IL-3. Interacts with receptors EPOR, MS4A2/FCER1B and FCER1G, FCGR2A, FCGR2B and FCGR3. Interacts with GRB2 and PLCG1. Interacts with tyrosine kinases SRC and TEC. Interacts with FCGR2A, leading to regulate gene expression during the phagocytic process. Interacts with c-Met/MET (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization (By similarity).

Tissue Specificity:
Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).

Post-translational modifications:
Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.

Similarity:
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
Contains 1 SH2 domain.

SWISS:
Q92835

Gene ID:
3635

Database links:

Entrez Gene: 3635 Human

Entrez Gene: 16331 Mouse

Omim: 601582 Human

SwissProt: Q92835 Human

SwissProt: Q9ES52 Mouse

Unigene: 262886 Human

Unigene: 601911 Human

Unigene: 15105 Mouse



產(chǎn)品圖片
Sample: RAW264.7(Mouse) Cell Lysate at 30 ug Raji(Human) Cell Lysate at 30 ug Primary: Anti-SHIP1 (bs-3567R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 133 kD Observed band size: 133 kD
版權(quán)所有 2004-2026 www.m.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
99热这里只有精品亚洲| 狠狠色伊人亚洲综合成人| 中日韩VA无码中文字幕| 找个日韩操逼的看看| 骚逼少妇被巨根爆插| 免费看澡美女逼视频看看| 亚洲 自拍 欧美 一区| 大香蕉操逼小视频| 国产午夜福利视频第三区| 老色鬼精品视频二区三区| 男人的天堂久久久久久久| 中文字幕乱码一区三区免费| 欧美日本大白屁股大黑逼操逼视频| 国产大码丝袜老熟女av| 久久久久有精品国产麻豆| 插到底啊啊啊视频| 喜欢被粗大阴茎插入| 97人妻精品一区二区三区视频| 久久久久久高清无码视频| 狠狠色伊人亚洲综合成人| 夫妻性生活在线免费视频| 欧美尤物操逼毛茸茸真爽| 99热这里只有精品亚洲| 好想插进去捅一捅| 国产成人无码91精品一区| 婷婷6月天丁香综合在线| 男生舔女生下面黄色视频| 亚洲女同一区二区三久久精品| 亚洲一区二区三成人精品| 日韩精品诱惑一区?区三区| 日韩欧美综合一二三区| 内射白嫩少妇超碰| 色婷婷五月综合久久| 两人爽爽爽无码免费视频| 亚洲欧美一区二区三区在| 国产亚洲欧美中文日韩| 国产精品粉嫩懂色av| 波多野结衣高潮尿喷| 国产精品免费久久久久久| 亚洲av伦理一区二区三区久久| 日韩av一区二区高清不卡|