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Rabbit Anti-IL17F  antibody (bs-2614R)  
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產(chǎn)品編號 bs-2614R
英文名稱 Rabbit Anti-IL17F  antibody
中文名稱 白介素-17F抗體
別    名 Interleukin 17F; Cytokine ML-1; IL-17F; IL17F_HUMAN; Interleukin-17F; CANDF6; ML1.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞表面分子  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 17 kDa
檢測分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-17F: 71-163/163 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

Function:
Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

DISEASE:
Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:613956]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Similarity:
Belongs to the IL-17 family.

SWISS:
Q96PD4

Gene ID:
112744

Database links:

Entrez Gene: 112744 Human

Omim: 606496 Human

SwissProt: Q96PD4 Human

Unigene: 272295 Human



產(chǎn)品圖片
Sample: RAW264.7 (Mouse)Cell Lysate at 30 ug Jurkat(Human) Cell Lysate at 30 ug HL-60(Human) Cell Lysate at 30 ug LOVO(Human) Cell Lysate at 30 ug Primary: Anti-IL17F (bs-2614R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kD Observed band size: 22 kD
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