| 產(chǎn)品編號(hào) | bs-2569R |
| 英文名稱 | CD226 Rabbit pAb |
| 中文名稱 | CD226抗體 |
| 別 名 | DNAX accessory molecule 1; adhesion glycoprotein; CD226 antigen; DNAM1; platelet and T cell activation antigen 1; PTA1; TLiSA1; CD226; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; T lineage specific activation antigen 1 antigen. |
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Specific References (1) | bs-2569R has been referenced in 1 publications.
[IF=15.304] Yao Lei. et al. Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors. BIOMATERIALS. 2022 Jun;:121635 WB, IF, FC ; Mouse.
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| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞粘附分子 細(xì)胞表面分子 細(xì)胞類型標(biāo)志物 自然殺傷細(xì)胞 淋巴細(xì)胞 t-淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=1μg/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 35 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD226: 201-300/336 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008] Subunit: Interacts with PVR and PVRL2. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed by peripheral blood T-lymphocytes. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q15762 Gene ID: 10666 Database links: Entrez Gene: 10666 Human Omim: 605397 Human SwissProt: Q15762 Human Unigene: 660130 Human CD226分子是一種廣泛表達(dá)于多種免疫細(xì)胞膜表面的Ⅰ型跨膜糖蛋白，CD226廣泛表達(dá)于T細(xì)胞、NK細(xì)胞、NK T細(xì)胞、活化的血管內(nèi)皮細(xì)胞、巨核/血小板譜系、單核細(xì)胞、胸腺細(xì)胞、某些B細(xì)胞亞群、部分造血干細(xì)胞和肥大細(xì)胞等免疫細(xì)胞表面，在免疫系統(tǒng)以外則分布于海馬和小腦皮質(zhì)的神經(jīng)突觸部位。CD226與其配體的相互作用參與CTL和NK細(xì)胞的活化、分化和細(xì)胞毒作用,調(diào)節(jié)CD4+ T細(xì)胞的增殖和分化，介導(dǎo)內(nèi)皮細(xì)胞與其他細(xì)胞的黏附,促進(jìn)血小板的活化與聚集，參與造血調(diào)控，介導(dǎo)肥大細(xì)胞的脫顆粒作用，參與NK T細(xì)胞和胸腺細(xì)胞的抗凋亡作用、樹突狀細(xì)胞的成熟、免疫突觸和神經(jīng)突觸的形成，并與腫瘤、自身免疫性疾病、移植排斥及病毒感染等疾病密切相關(guān)。 |
| 產(chǎn)品圖片 |
Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti-CD226 (bs-2569R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 35 kD
Blank control(blue): Jurkat cells(fixed with 2% paraformaldehyde (10 min) ). Primary Antibody:Rabbit Anti-CD226 antibody(bs-2569R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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