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PLAUR Rabbit pAb (bs-1927R)  
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產(chǎn)品編號 bs-1927R
英文名稱 PLAUR Rabbit pAb
中文名稱 尿激酶型纖溶酶原激活因子受體(CD87)抗體
別    名 Plasminogen activator, urokinase receptor; Urokinase plasminogen activator surface receptor; Monocyte activation antigen Mo3; U-PAR; U PAR; UPAR; MO3; MO 3; CD 87; CD87; Monocyte activation antigen Mo3; u plasminogen activator receptor; UPA receptor; Urinary plasminogen activator receptor; URKR; Urokinase plasminogen activator receptor;  
Specific References  (2)     |     bs-1927R has been referenced in 2 publications.
[IF=4.344] Daisuke Ito. et al. Systemic and topical administration of spermidine accelerates skin wound healing. Cell Commun Signal. 2021 Dec;19(1):1-12  WB ;  Mouse.  
[IF=3.263] Makuszewska, Maria. et al. Enhanced Expression of Plasminogen Activators and Inhibitor in the Healing of Tympanic Membrane Perforation in Rats. JARO-J ASSOC RES OTO. 2023 Feb;:1-12  IF,WB ;  Rat.  
研究領(lǐng)域 腫瘤  心血管  細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Sheep,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 31 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PLAUR: 201-300/335 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol(GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq].

Function:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Subcellular Location:
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Secreted (Probable).

Tissue Specificity:
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Similarity:
Contains 3 UPAR/Ly6 domains.

SWISS:
Q03405

Gene ID:
5329

Database links:

Entrez Gene: 5329 Human

Entrez Gene: 18793 Mouse

Entrez Gene: 50692 Rat

SwissProt: Q03405 Human

SwissProt: P35456 Mouse

SwissProt: P49616 Rat



產(chǎn)品圖片
Sample: bone (Mouse) Lysate at 40 ug Primary: Anti-uPA Receptor (bs-1927R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 48 kD
Sample: Lane 1: Cerebrum (Mouse) Tissue Lysate at 40 ug Lane 2: Cerebrum (Rat) Tissue Lysate at 40 ug Primary: Anti-uPA Receptor (bs-1927R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 48 kD
Tissue/cell: mouse adrenal gland; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-uPA Receptor Polyclonal Antibody, Unconjugated(bs-1927R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: mouse brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-uPA Receptor Polyclonal Antibody, Unconjugated(bs-1927R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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