| 產(chǎn)品編號 | bs-0928R |
| 英文名稱 | phospho-heterochromatin protein 1 (pTyr24) Rabbit pAb |
| 中文名稱 | 磷酸化異染色質(zhì)蛋白1抗體（果蠅） |
| 別 名 | heterochromatin protein 1(phospho Tyr24); heterochromatin protein 1(phospho Y24); Antigen p25; Cbx 5; Cbx5; Chromobox homolog 5(Drosophila HP1 alpha); Chromobox homolog 5(HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chr |
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Specific References (1) | bs-0928R has been referenced in 1 publications.
[IF=3.057] Terzuoli et al. Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation. (2014) PLoS.On. 9:e84358 WB ; Human.
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| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 免疫學(xué) 染色質(zhì)和核信號 昆蟲 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Fruit Fly) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from Fruit Fly HP1 around the phosphorylation site of Tyr24: EE(p-Y)AV |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane.
HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required
for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin. Database links: GenBank: ACI96782.1 異染色質(zhì)蛋白1（Heterochromatin protein 1 (HP1)）一般認(rèn)為是異染色質(zhì)的維持者，異染色質(zhì)是轉(zhuǎn)錄沉默的固縮DNA，常常與中心粒等區(qū)域有關(guān)。這種固縮的DNA被認(rèn)為是轉(zhuǎn)錄因子無法接近的，但近期的Science上發(fā)表的兩篇報(bào)道對這個(gè)觀點(diǎn)提出了挑戰(zhàn)。 這個(gè)新的研究提出HP1可能是異染色質(zhì)活性調(diào)控的重要因子，在細(xì)胞生理活動(dòng)中具有的重要功能。 |
