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Rabbit Anti-Neurturin  antibody (bs-0073R)  
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產(chǎn)品編號(hào) bs-0073R
英文名稱 Rabbit Anti-Neurturin  antibody
中文名稱 神經(jīng)營養(yǎng)因子抗體
別    名 Neurturin precursor; Neurturin; NRTN; NTN; NRTN_HUMAN.  
Specific References  (2)     |     bs-0073R has been referenced in 2 publications.
[IF=6.1] Jing Man. et al. TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway. BIOCHEM PHARMACOL. 2023 Jul;213:115615  ICC,WB ;  Human.  
[IF=2.46] Lu, Yanmei, et al. "Effect of Low-level Vagus Nerve Stimulation on Cardiac Remodeling in a Rapid Atrial Pacing–induced Canine Model of Atrial Fibrillation." Journal of cardiovascular pharmacology 67.3 (2016): 218-224.  IHC-P ;  Dog.  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 21 kDa
檢測(cè)分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neurturin: 151-197/197 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Human Neurturin (NTN) and Human GDNF comprise a family of TGF-beta related neurotrophic factor which have trophic influences on a variety of neuronal populations. Neurturin promotes the survival of certain sympathetic and sensory neurins through interaction with distinct set of GDNF-like receptors

Function:
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Secreted.

DISEASE:
Note=Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.

Similarity:
Belongs to the TGF-beta family. GDNF subfamily.

SWISS:
Q99748

Gene ID:
4902

Database links:

Entrez Gene: 4902 Human

Entrez Gene: 18188 Mouse

Entrez Gene: 84423 Rat

Omim: 602018 Human

SwissProt: Q99748 Human

SwissProt: P97463 Mouse

Unigene: 234775 Human

Unigene: 8074 Mouse

Unigene: 21952 Rat



產(chǎn)品圖片
Sample: Lane 1: Human K562 cell Lysates Lane 2: Human 293T cell Lysates Primary: Anti-Neurturin (bs-0073R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 21kDa Observed band size: 21kDa
Sample: Placenta(Mouse)lysate at 30 ug; Brain(Mouse) lysate at 30 ug; Primary: Anti- Neurturin (bs-0073R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size: 21 kD Observed band size: 21 kD
Tissue/cell: human breast carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Neurturin Polyclonal Antibody, Unconjugated(bs-0073R) 1:100, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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