| 產(chǎn)品編號(hào) | bs-1061R |
| 英文名稱 | MPO Rabbit pAb |
| 中文名稱 | 髓過氧化物酶抗體 |
| 別 名 | Myeloperoxidase; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN. |
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Specific References (4) | bs-1061R has been referenced in 4 publications.
[IF=17.694] Zhang, Shengchang. et al. Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice. NAT COMMUN. 2023 Feb;14(1):1-16 IHC ; Mouse.
[IF=6.064] Zhang Xuyang. et al. A modified method for constructing experimental rat periodontitis model. FRONT BIOENG BIOTECH. 2022 Dec;10:2451 IHC ; Rat.
[IF=4.86] Li et al. Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. (2013) Lab.Inves. 93:322-33 IHC ; Mouse.
[IF=2.05] Neupane S et al.Focal localization of inflammatory cytokines and neurotrophins in a tongue chronic injury model. (2019) Archives of Oral Biology 99, 22–30. IHC-P ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 激酶和磷酸酶 淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 84 kDa |
| 檢測分子量 | 15/55-60/84-90 |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Myeloperoxidase: 51-150/745 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Lysosome. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. Similarity: Belongs to the peroxidase family. XPO subfamily. SWISS: P05164 Gene ID: 4353 Database links: Entrez Gene: 4353 Human Entrez Gene: 17523 Mouse Omim: 606989 Human SwissProt: P05164 Human SwissProt: P11247 Mouse Unigene: 458272 Human Unigene: 4668 Mouse Unigene: 47782 Rat 髓過氧化物酶MPO,作為一種白細(xì)胞酶,具有介導(dǎo)炎性反應(yīng)、調(diào)節(jié)免疫應(yīng)答等多種功能,并可參與疾病的發(fā)生發(fā)展過程。同時(shí),髓過氧化物酶基因存在基因多態(tài)性,也影響機(jī)體對(duì)疾病的易感性. 在正常淋巴組織中和各種髓樣細(xì)胞增生癥中，MPO均有較強(qiáng)表達(dá)，如：淋巴樣細(xì)胞、原核細(xì)胞、肥大細(xì)胞、漿細(xì)胞以及各種上皮源性腫瘤和肉瘤等。 髓過氧化物酶(myeloperoxidase,MPO),是一種血紅素蛋白，富含于中性粒細(xì)胞中,由粒細(xì)胞進(jìn)入循環(huán)之前在骨髓內(nèi)合成并存儲(chǔ)于噬天青顆粒內(nèi)。外界刺激可導(dǎo)致中性粒細(xì)胞聚集，從而釋放髓過氧化物酶。MPO的相對(duì)分子量為150kDa，是由兩個(gè)亞單位通過共價(jià)結(jié)合形成的四聚體，每個(gè)亞單位又有一條重鏈α（相對(duì)分子量60kDa）和一條輕鏈β鏈（相對(duì)分子量為15kDa)構(gòu)成。（重鏈和輕鏈通過二硫鍵結(jié)合） |
