| 產(chǎn)品編號(hào) | bs-42429P |
| 英文名稱 | Recombinant Human SMARCA4 Protein，N-GST & C-His |
| 中文名稱 | 重組人抑癌基因SNF2β蛋白 |
| 別 名 | SMCA4_HUMAN; Transcription activator BRG1; EC:3.6.4.- ; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A (BAF190A); Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; BAF190A; BRG1; SNF2B; SNF2L4; SWI/SNF relat |
| 理論分子量 | 37.4kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 緩 沖 液 | 50mM Tris-Hcl (pH=8.0) with 10mM GSH and 1mM PMSF |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined. 轉(zhuǎn)錄調(diào)節(jié)因子（Transcriptin Regulators） SMARCA4是一種新的抑癌基因，已在許多腫瘤的研究中發(fā)現(xiàn)它是一種重要的抑癌基因，很多腫瘤的發(fā)生與其功能失活或出現(xiàn)基因突變、缺失相關(guān)聯(lián)。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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